Objective: In this study, we tried to identify the effects of stress on drinking problems and to check the mediated effects of stress response behavior on nursing college students. Methods: The number of people studied was 163, and the collected data was analyzed using the SPSS/WIN 21.0 statistical program. Hierarchical regression analysis was performed to analyze the mediated effects between stress and problem drinking. Results: Problem drinking showed a positive correlation with stress (r=.258, p≤.001) and also showed a positive correlation with coping (r=.226, p≤.005). In addition, as a result of verifying the mediating effect of avoidance coping, it was found that there was a partial mediation between stress and problem drinking (Z=3.08). Conclusion: In order to improve the mental health of nursing students with high stress levels, it is necessary to first check the level of stress and coping with it. It is necessary to provide a program that reduces avoidance coping and manages stress more efficiently.