Purpose: This study aims to explore the perception and acceptability of male and female adults on the proposed guidelines for low risk drinking. Method: Two focus group interviews were performed separately to explore the characteristics of drinking behavior and the level of acceptabilities on guidelines. Semantic network analysis was used to investigate the relationship between keywords, and some network characteristics were produced using community analysis with eigenvector centrality. Result: Each 22 and 29 meaningful key words were extracted from the male and female text, and it was found that four sub-communities constituted through community analysis. Key words related to social factors indicated high centrality in texts of both men and women, but they perceived the idea of reducing drinking differently. Conclusion: Most participants were reluctant or skeptical on practicing the proposed guidelines in terms of feasibility. As it is the introductory phase of adopting drinking guidelines, the findings suggest that more research findings through open discussion among general public and policy impact analysis should be undertaken to reflect the gender differences in drinking behavior, and to establish realistic and feasible approaches.