Objectives: The purpose of this study was to analyze the risk of illness according to the frequency of drinking by using Korean epidemiological data. Methods: The Cox regression model was analyzed using the National Health Insurance Cohort Database. The diseases analyzed included cancer, cerebrovascular disease, diabetes, liver disease, pancreatic disease, and epilepsy. Results: The risk of disease among high-risk drinkers is summarized as follows: esophageal cancer (6.1), laryngeal cancer (5.1), liver and pancreatic diseases (about 3 each), liver cancer (2.9), gastric cancer (2.5), rectal cancer (2.5), prostate cancer (2.2), and colon cancer (2.1). Conclusion: It is clear that the policy for the prevention and treatment of diseases of high-risk drinkers should be urgently implemented.