Objectives: The purpose of this study was to understand the effect of perceived stress of self-sufficiency programs participants on suicidal behavior and verify the moderating effects of the amount of drinking and drinking frequency in this relationship. Method: To achieve the research objectives, a survey of 279 participants from the Seoul self-sufficiency center was conducted, and in the analysis data from 271 participants were used. Results: Main results of the analysis are as follows. First, when the research model was tested, it was found that perceived stress of self-sufficiency program participants had a positive influence on their suicidal behavior. Second, the amount of drinking had a positive influence on suicidal behavior. Third, in the relationship between perceived stress and suicidal behavior, amount of drinking was found to have a moderating effect. Conclusion: Based on the results, we provided effective suggestions to decrease the suicidal behavior among self-sufficiency of program participants, who experienced perceived stress.