Purpose: The purpose of this study was to investigate the mediating effect of interpersonal relationships in associations between empowerment, quality of life, and treatment compliance for patients with alcohol use disorder. Method: The participants were patients with alcohol use disorder (n=160) who were admitted in the psychiatric hospital in D city. Data were collected using self-report questionnaires including the Empowerment scale, Relationship Change Scale (RCS), Insight and Treatment Attitude Questionnaire (ITAQ), and WHO Quality of Life Scale abbreviated version (WHOQOL-BREF). Data were analyzed with t-test, one-way ANOVA, Tukey test, Pearson correlation coefficient, and simple and multiple regression using the SPSS 20.0 program. The Baron and Kenny method and Sobel test were used to analyze the mediating effect. Results: Interpersonal relationships showed perfect mediating effect in the association between empowerment and treatment compliance, and had partial mediating effect in the association between empowerment and quality of life. Conclusion: The results of this study suggest that the development of nursing intervention is necessary for improvement of empowerment with regard to interpersonal relationships, and that it can improve treatment compliance and quality of life.